As a weight loss supplement, forskolin gained popularity in the United States after being featured on “The Dr. Oz Show” in January 2014.
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Forskolin is an active compound found in the roots of the Indian coleus (Coleus forskohlii), a tropical plant related to mint. For centuries, this plant has been used in traditional herbal medicine to treat various conditions and diseases (2Trusted Source).
Research now suggests that some of this compound’s potential health benefits — such as relief of cough, asthma symptoms, insomnia, and skin diseases — may be legitimate, or at least plausible (3Trusted Source, 4Trusted Source).
How do weight loss supplements work?
Weight loss supplements can allegedly promote weight loss in several ways, including by (5Trusted Source):
- reducing nutrient absorption
- increasing the breakdown of fats
- boosting energy expenditure
- reducing hunger levels
Because your body needs to break down nutrients in order to absorb them, supplements that reduce nutrient absorption often target different enzymes in charge of nutrient digestion.
For instance, some supplements block an enzyme called pancreatic lipase, which reduces fat absorption. In contrast, others inhibit enzymes such as amylase and glucosidase, preventing the digestion and absorption of carbs.
In both cases, the supplement promotes weight loss by reducing energy intake (5Trusted Source).
Furthermore, supplements that increase the breakdown of fats — also known as fat burners — reportedly work either by reducing fat accumulation or by preventing the formation of fat, a process called lipogenesis (6Trusted Source).
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Supplements that boost your energy expenditure, such as caffeine, mostly rely on their thermogenic effect — an ability to produce heat.
This leads to an increased resting energy expenditure — the number of calories your body burns while resting — and thus promotes fat loss (7Trusted Source).
Lastly, supplements that help reduce hunger act by increasing the levels of hormones that promote feelings of fullness, such as peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), and reducing the levels of hunger-promoting hormones such as ghrelin (5Trusted Source).
Does forskolin actually help you lose weight?
While some studies have investigated the effects of forskolin on fat metabolism, most have been test-tube experiments or animal studies, so their results may not apply to humans. Recent human research is scarce.
Forskolin is believed to promote the production of hormone-sensitive lipase, an enzyme involved in moving stored triglycerides and releasing fatty acids so your body can use them for energy (8).
In simple terms, forskolin is thought to reduce the size of fat cells by promoting the breakdown of fats. The same happens whenever your body needs to use fat as fuel (2Trusted Source).
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Nevertheless, the release of stored fat is not enough to promote weight loss on its own. It needs to be accompanied by a calorie deficit.
In other words, for weight loss to happen, energy expenditure (calories out) must exceed energy intake (calories in), which is precisely what was determined in a small 2015 study (9Trusted Source).
The researchers recruited 30 men with overweight or obesity. Twice a day for 12 weeks, the participants took either 250 mg of Coleus forskohlii extract (10% forskolin) or a placebo.
At the end of the trial, there were no significant weight loss differences between the groups. However, both groups showed reductions in waist and hip circumference, which were attributed to the calorie restriction rather than to forskolin (9Trusted Source).
Nonetheless, an older 2005 study in 30 men with overweight or obesity suggested that forskolin may promote fat loss while preserving muscle mass (10Trusted Source).
There was also a significant increase in free testosterone in the forskolin group. Testosterone can stimulate the release of fat from fat cells and promote an increase in muscle mass, which may partly explain the study’s results (10Trusted Source, 11Trusted Source).
All that being said, the current evidence is not strong enough to make any recommendations. More research is needed (12Trusted Source).
